Meta ESM-2 Fold - AI faster than Alphafold 2

In this video I go over latest progress from Meta on protein folding, their ESM-2 model used to predict structures of metagenic proteins. This is a big step forward in the field. In the paper they compare the performance to Alphafold 2 and RoseTTA. Paper Title: Evolutionary-scale prediction of atomic level protein structure with a language model Abstract: Artificial intelligence has the potential to open insight into the structure of proteins at the scale of evolution. It has only recently been possible to extend protein structure prediction to two hundred million cataloged proteins. Characterizing the structures of the exponentially growing billions of protein sequences revealed by large scale gene sequencing experiments would necessitate a breakthrough in the speed of folding. Here we show that direct inference of structure from primary sequence using a large language model enables an order of magnitude speed-up in high resolution structure prediction. Leveraging the insight that langu