Total Synthesis of Hypersampsone M
An organic chemistry minilecture on the 'Total Synthesis of Hypersampsone M' by Adrian E. Samkian, Scott C. Virgil,* and Brian M. Stoltz*. It features an innovative ring expansion rearrangement, zincate addition-annulation and an aldol cyclization-lactonization sequence.
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References:
J. Am. Chem. Soc. 2024, 146, 28, 18886–18891 (This work)
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J. Am. Chem. Soc. 2017, 139, 6, 2484–2503 (HAT Coupling)
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Org. Lett. 2012, 14, 1, 214–217 (Amidation)
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